Hypothalamic-pituitary-thyroid axis set point alterations are associated with body composition in androgen-deprived men

Abstract

Objective: Androgen deprivation therapy (ADT) given to men with prostate cancer is associated with metabolically adverse changes in body composition leading to insulin resistance, but the underlying mechanisms are not fully understood. We investigated prospectively whether androgen deprivation or its consequences may be associated with alterations in thyroid function in men. Design: We performed a prespecified secondary analysis of a prospective case control study. Methods: We prospectively followed men with nonmetastatic prostate cancer newly commencing ADT (n = 34) and age-matched controls (n = 29) for 12 months. We assessed secondary outcomes on thyrotropin (TSH) and thyroid hormones usin..